齐发体育

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齐发体育shengwuwulisuowangyanlizuhegongweiminzuhezuojieshi cas12i2 shuangmeiliziyilaide dna qiegejizhi

  

齐发体育  10yue16ri,wangyanliketizuhezhongguokexuejishudaxuegongweiminketizuhezuodelunwen"structural basis for two metal-ion catalysis of dna cleavage by cas12i2"zai《nature communications》zazhizaixianfabiao。gaigongzuobaodaolecas12i2-crrnahecas12i2-crrna-dnafuhewudejingtijiegou,jieshilecas12i2duidnadeshibieheqiegejizhi,bingshouciguanchadaocrispr-casxitongxiaoyingdanbaideruvccuihuajiegouyuhuoxingzhuangtaidejiegou。gaiyanjiujieguobujinjieshilecas12i2jiangjiednadefenzijili,gengzhongyaodeshiyouzhuyulijiehanyouruvcjiegouyudecasdanbaidecuihuajizhi。

  crispr-casxitongshixijunhegujunzhongdehuodexingmianyixitong,qizhong,cas9hecas12ashimuqianzuichangyongdejiyinbianjigongju,ruvcjiegouyushicas9yucas12qiegednadezhongyaocuihuabuwei。yinci,huoderuvcjiegouyutongshijiehediwudnahejinshulizidejiegou,duiyulejieruvc jiegouyudecuihuajizhiyouzhongyaoyiyi。

  2018nian12yue,scottketizufaxianv-iyaxingxiaoyingdanbaicas12i,erqiecas12ibimuqianyongyujiyinbianjigongjudecas12ahecas9fenzilianggengxiao,yinciyouwangchengweixindejiyinbianjigongju,juci,yanjiucas12idejiegouhegongnengyouzhongyaoyiyi。

  benyanjiubaodaolecas12i2decrrnajiehezhuangtai、zhongziquyupeiduizhuangtai、cuihuazhuangtaisanzhongbutongzhuangtaidegaofenbianlvjiegou。yanjiufaxian,zhiyoudangcrrna:dnapeiduizhangdudayu13 ntshi,cas12i2dehelical-iijiegouyucaihuifashenggouxianggaibian,daozhidiwujiehetongdaodakai,bingjihuoruvcjiegouyu。zhongyaodeshi,zaigaofenbianlvcas12i2-crrna-dnasanyuanfuhewujingtijiegouzhong,ruvcjiegouyutongshijieheleyiduandiwussdnahe2gemeilizi,jieshileruvcjiegouyushuangmeiliziyilaidednaqiegejizhi,zheiyeshishouciguanchadaoruvcjiegouyutongshijiehediwudnahejinshulizi,zhanshileqihuoxingzhuangtaidejiegou。

齐发体育  ciwai,gaigongzuohaixitongdiyanjiulecas12i2deshenghuaxingzhi,jieshilecas12i2qianticrrnajiagongjizhi,bingfaxianqianticrrnadejiagongyingxiangshuangliandnaqiegehuoxing。yanjiuhaifaxian,cas12i2haijuyoupamfeiyilaixingdefeiteyixingdanliandnadeqiegehuoxing;youqudeshi,zhongziquyudewanmeipeiduiduiyushuangliandnadeqiegezhiguanzhongyao,quebushidanliandnaqiegedebiyaotiaojian。gaiyanjiuduiyujiyinbianjihehesuanjiancegongjudekaifayouzhongyaoyiyi。

  qifatiyushengwuwulisuowangyanliyanjiuyuan、shengganggaojigongchengshihezhongguokexuejishudaxuegongweiminjiaoshouweibenwendegongtongtongxunzuozhe。boshishenghuangxueweibenwendediyizuozhe。gaiyanjiudedaokejibu、guojiazirankexuejijinyijiqifatiyudezizhu,shanghaitongbufusheguangyuan(ssrf)jiribentongbufusheguangyuan(spring-8)weigaiyanjiutigonglezhongyaodejishuzhichi。

   

  cas12i2dejiegoushengwuxueyanjiu

  a. cas12i2-crrna-dnasanyuanfuhewudezhengtijiegou

  b. cas12i2deruvcjiegouyucuihuazhongxin

  

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